Lyophilization of ImunoparvumR° as an alternative to reduce its side-effects

Authors

  • Onaldo G. Rodrigues Universidade Federal de Campina Grande
  • Gilmar T. de Araújo Universidade Federal de Campina Grande
  • Hercília M. L. Rolim Universidade Federal de Pernambuco
  • Silene C. Nascimento Universidade Federal de Pernambuco
  • Luana C. B. B. Coelho Universidade Federal de Pernambuco

Keywords:

Imunoparvum, hipersensitividade, câncer, fenol, adjuvante

Abstract

In Brazil, Imunoparvum R° is used as an immunomodulator. It is commercialized in 2 ml ampoules containing 2 mg of Propionebacterium acnes (formerly known as Corynebacterium parvum)/ml, in a 0.5 % phenol and 0.85% sodium chloride solution. High therapeutic power associated to minimum side effects is a great challenge to the pharmaceuticalindustry. Research results have shown that Imunoparvum R° induces side effects in humans and animals, probably because of its phenol content (SOUSA, 1993; RODRIGUES, 2001). The objective of this study was to determine the phenol content of lyophilized and non-lyophilized Imunoparvum R° and to compare their side effects in mice. It was demonstrated that the lyophilization process reduces the phenol content and the side effects of Imunoparvum R°, when compared to the commercialized Propionebacterium acnes suspension.

Author Biographies

Onaldo G. Rodrigues, Universidade Federal de Campina Grande

Universidade Federal de Campina Grande - Centro de Saúde e Tecnologia Rural – Campina Grande

Gilmar T. de Araújo, Universidade Federal de Campina Grande

Universidade Federal de Campina Grande - Centro de Saúde e Tecnologia Rural – Campina Grande

Hercília M. L. Rolim, Universidade Federal de Pernambuco

Universidade Federal de Pernambuco - Centro de Ciências da Saúde - Recife, PE

Silene C. Nascimento, Universidade Federal de Pernambuco

Universidade Federal de Pernambuco - Centro de Ciências Biológicas

Luana C. B. B. Coelho, Universidade Federal de Pernambuco

Universidade Federal de Pernambuco - Centro de Ciências Biológicas

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Published

16-12-2009

Issue

Vol. 4 No. 1 (2002)

Section

Artigos

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